Introduction to pharmacology and its scope
Pharmacokinetics
- Definition and clinical significance of pharmacokinetics
- Physicochemical characteristics of drugs
- Pharmacokinetic analysis
- Zero-order and first-order kinetics
- One two and multi compartment models
- Non compartmental kinetics
- Kinetics of drug absorption
- Distribution and elimination
- Half life and volume of distribution in pharmacokinetics
- Organ and whole body clearance
- Single dose
- Multiple dose and constant infusion
- Kinetics PK / PD correlation
- Non-linear Pharmacokinetics
- Population pharmacokinetic
- Models and bayesian forecasting applied to clinical pharmacokinetics
Pharmacodynamics
- Drug receptors and drug action
- Specificity of drug action
- Types of drug antagonism
- Potency and efficacy
- Factors modifying the action & dosage of drugs
- Drug dosing
Principles of drug development
- History of drug discovery and development
- Modern techniques in drug screening drug
- Development process
- Preclinical testing
- Clinical phases of drug development
- Regulatory aspects of dd
- Types of drug applications
- Marketing and post marketing surveillance
- Generic drugs