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General Principles of Pharmacology: Course Outline (101)

Pharmacology focuses on the molecular and cellular mechanisms whereby therapeutic drugs, or other pharmacologically or toxicologically active compounds interact with biological, particularly human, system.

Course Outline

Introduction to pharmacology and its scope 

Pharmacokinetics 

  • Definition and clinical significance of pharmacokinetics
  • Physicochemical characteristics of drugs
  • Pharmacokinetic analysis
  • Zero-order and first-order kinetics
  • One two and multi compartment models
  • Non compartmental kinetics
  • Kinetics of drug absorption
  • Distribution and elimination
  • Half life and volume of distribution in pharmacokinetics
  • Organ and whole body clearance
  • Single dose
  • Multiple dose and constant infusion
  • Kinetics PK / PD correlation
  • Non-linear Pharmacokinetics
  • Population pharmacokinetic
  • Models and bayesian forecasting applied to clinical pharmacokinetics

Pharmacodynamics 

  • Drug receptors and drug action
  • Specificity of drug action
  • Types of drug antagonism
  • Potency and efficacy
  • Factors modifying the action & dosage of drugs
  • Drug dosing

Principles of drug development

  • History of drug discovery and development
  • Modern techniques in drug screening drug
  • Development process
  • Preclinical testing
  • Clinical phases of drug development
  • Regulatory aspects of dd
  • Types of drug applications
  • Marketing and post marketing surveillance
  • Generic drugs

Relevant Books

E Books