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Medicinal Chemistry I: Course Outline (P-I)

This course gives you the practical skills and knowledge to design and synthesise molecules that have therapeutic actions within the body.

Course Outline

Antibiotics

  • Penicillin
  • Cephalosporines
  • Tetracycline
  • Macroloids  
  • Amino glycosides
  • Quinolones
  • Chemistry and synthesis of semisynthetic antibiotics
  • Biosynthesis structure activity relationship
  • Historical background
  • Chemical classification
  • Nomenclature
  • Stereochemistry production
  • Mechanism of action & resistance

Steroids/ terpenoids

  • Steroid numbering nomenclature stereochemistry
  • Chemistry & biosynthesis of terpenoids and steroids
  • Citral  
  • Menthol
  • Camphor
  • Serotonin
  • Artemisinen
  • Taxol
  • Teroidal hormones
  • Sex hormones
  • Contraceptive  agents
  • Androgens
  • Adrenal cortex hormones
  • Cardiovascular drugs and steroids hormone receptors
  • Digoxin etc

Alkaloidal drugs

  • Structure
  • Nomenclature
  • Tereochemistry
  • Chemistry
  • General reactions
  • Biosynthesis
  • Mechanism of drug action etc
  • Ephedrine
  • Amphetamines
  • Hyocyamines
  • Cocaine
  • Morphine
  • Codeine
  • Heroin
  • Papaverine
  • Vincristine
  • Vinblastine
  • Reserpine
  • Lysergic acid diethy l amides (LSD)
  • Quinine
  • Quinidine (antimalarials)

 Phenolic drugs

  • Cinnamic acid
  • Coumarins
  • Flavones X
  • anthones
  • Tetrahydro cannibol and related compounds

Oils or fats

  • History
  • discovery
  • biosynthesis
  • mechanism of drug action
  • cox-2 inhibitors and receptors
  • Eicosanoids in clinical development for treatment
  • Eicosanoids prostaglandins
  • thromboxanes and leukotrienes

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