Immunology and Serology (IMSL-201) (MLT): Course Content (MLT- MLIS-513)

• Historical background, general concepts of the immune system, innate and adaptive

            immunity; active and passive immunity; primary and secondary immune response. Cell and
            organs of immune system, Phagocytosis, Innate immunity and cell mediated immunity.

• Antigens and immunogens: Properties,foreignness, molecular size, heterogeneity, B and T

            cell epitopes; T dependent and T independent antigens.

• Antibodies: Historical perspective of antibody structure; structure, function and properties

           of the antibodies; different classes, subclasses and biological activities of antibodies;
           concepts of antibody diversity, isotype, allotype.

• Introduction of hybridoma technology, monoclonal antibodies, polyclonal antibody
• Mechanism of humoral and cell mediated immune response.
•  Introduction of Major Histocompatibility Complex, organization of MHC and inheritance in

humans; Antigen presenting cells, antigen processing and presentation Complement system
and complement fixation test.

• Complement system
•  Introduction of transplant immunology, graft rejection, tissue typing for kidney and

             bone marrow transplant, Laboratory test for transplant.

•  Autoimmune disorders, pathogenesis, organ specific and systemic autoimmune

             disorders and its markers such parietal cell antibody, anti sperm antibody, lupus
             anticoagulants, anti mitochondrial antibody, ANA, ds DNA, HLA-B27, ASMA, anti CCP

•  Immunological disorders: primary and secondary immunodeficiency, SCID, AIDS,
• Tumour, types of tumours, Various Tumour Markers, their significance and method of

            estimation.

• Vaccines, classification and applications, Active and passive immunization,
• Immunoprophylaxis schedule in neonates, children and in pregnancy
•  Hypersensitivity and its types Introduction to Allergy and its laboratory test