Biochemistry: Pharmaceutical Chemistry-IIA (314) (315)

Biochemistry is a branch of science concerned with the chemical and physico-chemical processes and substances which occur within living organisms.

Pharmaceutical Chemistry

Course Content

1. GENERAL INTRODUCTION AND BASIC BIOCHEMICAL PRINCIPLES:

Role of pharmaceutical Biochemistry in the health Profession. Nature of Biochemical reactions.

2. BASIC CHEMISTRY OF BIOMOLECULES: (Nature, Classification etc.)

a) Carbohydrates: Chemistry, Classification, Reactions of Carbohydrates, Optical activity, Biological and pharmaceutical importance of carbohydrates.

b) Lipids: Chemistry of Fatty acids and Lipids, Classification (Saponifiable and non- saponifiable lipids, Simple, Complex and derived lipids), Reactions of Fatty acids and other Lipids, Essential fatty acids, Biological and pharmaceutical importance of lipids.

c) Proteins and Amino acids: Chemistry, Classification of proteins and amino acids, Reactions of proteins and amino acids, Organizationallevels, Macromolecular nature of proteins, Biological and pharmaceutical importance of proteins and amino acids.

d) Nucleic acids: Chemistry, Types (DNA, RNA, mRNA, tRNA, rRNA), Purine and Pyrimidine bases, Nucelosides, Nucelotides, Structures of nucleic acids, Biological and pharmaceutical importance of nucleic acids.

e) Vitamins: Chemistry, Classification (Fat-soluble and water- soluble vitamins), Biological and pharmaceutical importance of vitamins.

f) Hormones: Chemistry, Classification (Proteinous and nonproteinous hormones, amino acid derivatives, steroids), Biological and pharmaceutical importance of hormones.

g) Enzymes: Chemistry, Classification, Mode of action, Kinetics (Michaelis Menten Equation and some modifications), Inhibition, Activation, Specificity, Allosteric enzymes, Factors affecting the rate of an enzyme-catalyzed reaction, Biological and pharmaceutical importance, Mechanism of action of some important enzymes (Chymotrypsin, Ribonuclease).