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Medicinal Chemistry II: Course Outline (P-II)

Course work requires our graduate students to achieve a level of proficiency in organic, medicinal and physical chemistry, pharmacology, biochemistry, and molecular biology.

Course Outline

Antimalarials

  • Mechanism of action
  • Mechanism of resistance of 4-Aminoquinolines
  • 8-Aminoquinolines
  • Acridines analogous and pyrimethamine
  • Structure activity relationship

Antiviral

  • Targets for the prevention of viral infection
  • Mechanism of action
  • Synthesis and structure activity relationship of antiviral drugs
  • Newer agents for the treatment of HIV infection

 Antineoplastic

  • Tumor cell properties
  • Alkylating agents
  • Antimetabolites
  • Miscellaneous compounds

Antifungal agents

  • Introduction mechanism of action and structure activity relationship of different classes

Central nervous system depressants

  • General anesthetics (Volatile and barbiturates) sedatives and hypnotics
  • Benzodiazepines
  • aldehydes and alcohols

Central Nervous System stimulants

  • Antidepressants
  • Analeptics
  • Methylxanthines​

Diuretics

  • Introductions
  • Carbonic anhydrase inhibitor
  • Thiazides and thiazide like diuretics
  • Loop diuretics
  • Potassium sparing diuretics and miscellaneous diuretics

Cardiovascular Agents

  • Antianginal
  • antihypertensive
  • Synthetic hypoglycemic agents and vasodilator

Analgesics

  • Nonsteroidal anti-inflammatory agents
  • Mechanism of actions
  • Synthesis and structure activity relationship

Antitubercular drugs

  • Introduction mechanism of action
  • Synthesis and structure activity relationship of INH
  • Pyrazinamide
  • Ethambutol
  • Ethionamide
  • Rifampine
  • Streptomycines
  • aminosalycylic acids

Combinatorial Chemistry

  • Application in drug discovery

 

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