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Advance pharmaceutical organic chemistry: Course Outline (901)

The course is designed for both chemistry graduates and those with degrees in combined sciences which include a chemistry component, and aims to enhance their broad understanding of chemistry and perfect their skills in underlying aspects of organic chemi

Course Outline


  • Elements of symmetry
  • Plane of symmetry and center of symmetry
  • Alternating axis of symmetry
  • Simple axis of symmetry

Kinds of molecules displaying optical activity

  • Compounds with a chiral carbon atom
  • Compounds with other quadrivalent chiral atoms
  • Compounds with tervalent chiral atoms suitably substituted adamantanes​

Optical isomerism in compounds containing no chiral atom

  • Biphenyls
  • Allenes
  • Compounds with exocylic double bonds
  • Spiranes
  • Chirality due to a helical shape
  • Chirality caused by restricted rotation of other types

Cis-trans isomerism

  • Resulting from double bonds
  • Monocyclic compounds
  • Fused ring systems
  • Out-in isomerism
  • Enantiotopic and diastereotopic atoms
  • Groups and faces chirality and importance of chiral drugs
  • Techniques for preparing chiral drugs (chirality pool
  • Enzymatic transformation and assymetric synthesis)


  • Carbon to carbon migration
  • Carbon to oxygen and oxygen to carbon migration
  • Nitrogen to carbon
  • Oxygen to carbon migrations

Elimination reactions

  • E2 E1 and E1cb mechanisms
  • Orientation effects in elimination reactions stereochemistry of E2 elimination reactions elimination not involving C-H bonds

Substitution reactions

Electrophilic aromatic substitution

  • Nitration
  • Halogenations​

Friedel crafts alkylations and acylations 

nucleophilic aromatic substitution

  • Aromatic diazonium ions as synthetic intermediates
  • Substitution by the addition-elimination mechanism
  • Substitution by the elimination-addition mechanism
  • Substituion by the SN1 mechanism
  • Additions reactions


Relevant Books