Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

Advance pharmaceutical organic chemistry: Course Outline (901)

The course is designed for both chemistry graduates and those with degrees in combined sciences which include a chemistry component, and aims to enhance their broad understanding of chemistry and perfect their skills in underlying aspects of organic chemi

Course Outline

Stereochemistry

  • Elements of symmetry
  • Plane of symmetry and center of symmetry
  • Alternating axis of symmetry
  • Simple axis of symmetry

Kinds of molecules displaying optical activity

  • Compounds with a chiral carbon atom
  • Compounds with other quadrivalent chiral atoms
  • Compounds with tervalent chiral atoms suitably substituted adamantanes​

Optical isomerism in compounds containing no chiral atom

  • Biphenyls
  • Allenes
  • Compounds with exocylic double bonds
  • Spiranes
  • Chirality due to a helical shape
  • Chirality caused by restricted rotation of other types

Cis-trans isomerism

  • Resulting from double bonds
  • Monocyclic compounds
  • Fused ring systems
  • Out-in isomerism
  • Enantiotopic and diastereotopic atoms
  • Groups and faces chirality and importance of chiral drugs
  • Techniques for preparing chiral drugs (chirality pool
  • Enzymatic transformation and assymetric synthesis)

Rearrangements

  • Carbon to carbon migration
  • Carbon to oxygen and oxygen to carbon migration
  • Nitrogen to carbon
  • Oxygen to carbon migrations

Elimination reactions

  • E2 E1 and E1cb mechanisms
  • Orientation effects in elimination reactions stereochemistry of E2 elimination reactions elimination not involving C-H bonds

Substitution reactions

Electrophilic aromatic substitution

  • Nitration
  • Halogenations​

Friedel crafts alkylations and acylations 

nucleophilic aromatic substitution

  • Aromatic diazonium ions as synthetic intermediates
  • Substitution by the addition-elimination mechanism
  • Substitution by the elimination-addition mechanism
  • Substituion by the SN1 mechanism
  • Additions reactions

 

Relevant Books

E-Books

E-Books