This course covers the brief overview of the cellular & molecular biology, membrane physiology, introduction to molecular medicine and gene therapy, nuclear transplantation, gene therapy for neurological disorders, gene therapy for musculoskeletal disorders and the concept of molecular medicine in physical therapy. This course has been designed to address a more in depth study of biology of inheritance and inheritance patterns. This course focuses on classical Mendelian genetics, the DNA molecule and molecular genetics, and population genetics. The course also covers Human genome and Molecular Pathology.
BRIEF REVIEW OF CELLULAR & MOLECULAR BIOLOGY
Structure and Functions of Cell, - Nucliec Acid, - Chromosomes & Proteins
NTRODUCTION TO MOLECULAR MEDICINE AND GENE THERAPY
Introduction Genetic - Manifestations of Molecular Medicine - Gene Therapy and Patterns of Gene Expression - Gene Therapy and Molecular Medicine Gene Therapy: Current Basic Science Issues Human Gene Therapy: Current Status and Basic Science
GENE THERAPY FOR NEUROLOGICAL DISORDERS:
Sorting Out the Complexity of the Nervous System What Goes Wrong in Neurological Disorders Neurotophic Factors and Gene Therapy Neural Transplants and Stem Cells Clinical Neurodegenerative Conditions Clinical Trials Testing Genetically Modified Cells and Neurotrophic Factors for Neurodegeneration: Stem Cell Therapy in Spinal Cord Injuries Future Considerations and Issues
GENE THERAPY FOR MUSCULOSKELETAL DISORDERS
Regulatory Factors in Bone Development and Regeneration: o
Cells for Gene Therapy Strategies Directed Towards Bone Regeneration
In Vivo& Ex Vivo Gene Therapy Strategies for Bone
Clinical Trials for Bone Replacement Ligament and Tendon
Introduction o Ligament and Tendon Growth Factors
Cells for Gene Therapy Strategies Directed Towards Ligament Regeneration
In Vivo &Ex Vivo Gene Therapy Strategies to Intact Ligament and Tendon
Gene Therapy Strategies for Lacerated Tendon Repair, promote Osseo-Integration of Tendon Grafts o Clinical Trials for Ligament and Tendon Replacement: Cartilage:
Introduction o Growth Factors and Cytokines for Cartilage Repair and Regeneration
Cells for Gene Therapy Strategies Directed Towards Cartilage Regeneration
Gene Delivery Strategies for Cartilage Repair and Regeneration
Dose Dependency Detected with Cartilage Gene Therapies
Therapeutic Effects by Transfected Cells on Distal Joints
Transfected Xenogenic Cells for Cartilage Repair
Cartilage Tissue Engineering and Gene Therapy Intervertebral Disc
Introduction o The Biology of Intervertebral Disc Degeneration
Application of Gene Therapy in Intervertebral Disc
In Vivo& Ex Vivo Gene Therapy Strategies to Intervertebral Disc
Clinical Trials for Intervertebral Disc Muscles o Introduction
The Molecular Basis of Myopathies
In Vivo& Ex Vivo Gene Therapy Strategies in Myopathies
Clinical Trials in Myopathies
Gene Therapy: Ethical Issues at the Policy Level A brief introduction to following topics
The chemistry of dna Dna replication and recombination Transcription, translation and protein synthesis Cell-based dna cloning
Nucleic acid hybridization assays:
Pcr, dna sequencing and in vitro mutagenesis:
Organization of the human genome:
Human gene expression:
Instability of the human genome:
Mutation and dna repair:
Physical and transcript mapping:
Molecular Neuropharmacology: a Foundation for Clinical Neuroscience, Third Edition by 
Molecular Markers, Natural History, and Evolution by 
