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Organic Chemistry: Pharmaceutical Chemistry-IB

This guide comprises of two courses Pharmaceutical Chemistry-IA and Pharmaceutical Chemistry-IB

Course Contents

1. HETEROCYCLIC CHEMISTRY

i. Preparation and proper ties of medicinally important Hetrocyclic Compounds such as pyrool, furan, thiophene, pyridine, pyrimidine and pyrazine.

ii. Preparation and properties of hetrocyclic compounds in which benzo-ring is fused with five and six membered ring containing one heteroatom; Indole, Quinoline and Isoquinoline.

2. REACTION MECHANISM

Organic Reaction Mechanism: Arndt-Eisteret Baeyer-Villiger oxidation: Diels Alder reaction; Grignard‘s reaction, Metal hydride reduction and wolf krishnner reduction friedel craft‘s reaction, Perkin reaction, Cannizzaro reaction. Mannich Reaction

3. REACTIVE INTERMEDIATES AND FREE RADICALS:

Introduction, Generation, stability and Reaction of the following intermediates: Carbocations, Carbanions, Carbenes, Nitrenes,Benzynes, Type of reactions: An Overview. Free radicals, Free radical scavengers and their applications.

4. CARBONIUM ION REARRANGEMENTS:

Pinacol-Pinacolone, wigner-Meerwein, Wolf, Hofmann and Beckmann rearrangements.

5. CARBANIONS: Condensation reaction (Aldol condensation Favorskii rearrangement; writing reaction)

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