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Medicinal Chemistry: Pharmaceutical Chemistry-IVA

Medicinal chemistry is a chemistry-based discipline, also involving aspects of biological, medical and pharmaceutical sciences.

Course Outline

1. Introduction To Medicinal Chemistry:

Chemical constitution and biological activity: (Receptor, Theory, Structure Activity Relationships (SAR) and Drug Metabolism). Modern concept of rational drug design, pro drug, combinatorial chemistry and computer aided drug design (CADD) and concept of antisense molecules.

2. Drug Targets And Drug Designing:

i. Introduction and types of Drug targets

ii. Introduction to Molecular modeling and computational chemistry

iii. Structure based designing

iv. Ligand-based designing

v. Various techniques in drug synthesis.

3. General Properties, Chemistry Biological Action, Structure Activity Relationship And Therapeutic Applications Of The Following:

a. Hormones: Steroidal Hormones (Testosterone, Progesterone, Estrogen, Aldosteron and Cortisol), Proteinous Hormones (Insulin, Glucagon, Oxytocin and Vassopressin).

b. Anti-neoplastic Agents: Tamoxifen, Fluorouracil, Mercapturine, Methotrexate and Vincristine.

c. Sedatives, & Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde, Glutethimide, Chloral hydrate, and alcohols.

d. Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine, Cocaine and Benzocaine), General anaesthetics (Cyclopropane, Halothane, Nitrous oxide, Chloroform, Thiopental Sodium, Ketamine, Methohexital, Thioamylal Sodium, Fantanyl Citrate, Tribromo ethanol).

e. Analgesics and Antipyretics: Paracetamol, Salicylic acid analogues, Quinolines derivatives, Pyrazolone and Pyrazolo Pyrazolodiones, N - arylanthranilic acids, Aryl and heteroaryl acetic acid derivatives. 

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