Pharmacology: Course Outline (412-IA)
Pharmacology is the science of drug action on biological systems. In its entirety, it embraces knowledge of the sources, chemical properties, biological effects and therapeutic uses of drugs.
Course Outline
General pharmacology
Pharmacology​
- Definition of pharmacology
- History and its various branches
- Definition of drug and its various sources
Routes of drug administration
- Advantages and disadvantages
Pharmacokinetics
- Drug solubility and passage of drug across the biological membranes
- Absorption & distribution
- Metabolism and elimination of drugs and factors affecting them
- Various pharmacokinetic parameters including volume of distribution (vd)
- Clearance (cl)
- Biological half life (t1/2β) bioavailability and various factors affecting it dose
- Efficacy and potency of drugs
- Hypersensitivity and idiosyncratic reactions
- Drug tolerance and dependence
- Drug interactions
- Plasma protein binding
Pharmacodynamics
- How drugs act? receptors and their various types with special reference to their molecular structures
- Cell surface receptors
- Signal transduction by cell surface receptors
- Signaling Mediated by intra cellular receptors
- Target cell and hyper sensitization
- Pharmacological effects not mediated by receptors (for example anesthetics and cathartics) Ion channel
- Enzymes
- Carrier proteins
- Drug receptor interactions and theories of drug action
- Agonist
- Antagonist
- Partial agonist
- Inverse agonist
- Receptors internalization and receptors co-localization
- Physiological antagonism
- Pharmacological antagonism (competitive and non-competitive)
- Neutralization antagonism
- Neurotransmission and neuro-modulation
- Specificity of drug action and factors modifying the action & dosage of drugs
- Median lethal dose (LD:50)
- Median effective dose (ED:50) and therapeutic index
- Dose-response relationships
Drugs acting on autonomic nervous system (ans)
Organization of ANS its subdivisions and innervations
Neurotransmitters in ANS their synthesis release and fate
Sympathetic agonists
- Catecholamines and noncatecholamines
Sympathetic antagonists
- Adrenergic receptor blockers and neuron blockers
Parasympathetic (Cholinergic) agonists and cholinesterase enzyme inhibitors (anticholinesterases) parasympathetic antagonists
Ganglion stimulants and Ganglion blocker
Neuromuscular blockers
Drugs acting on gastrointestinal tract
Emetic and anti-emetics
Purgatives
Anti-diarrheal agents
Treatment of peptic & duodenal ulcer
- Antacids
- H2-Receptor antagonists
- Antimuscarinic agents
- Proton pump inhibitors
- Prostaglandin antagonists
- Gastrin receptor antagonist and cytoprotective agents
Drug treatment of chronic inflammatory bowel diseases
Drugs affecting bile flow and cholelithiasis
Relevant Books
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The Pharmacological Basis of Therapeutics by
Call Number: 615.7 GOOISBN: 9780071624428Publication Date: 2011 -
Pharmacology an illustrated review with questions and explanations by
Call Number: 615.1 EBAISBN: 0316199575Publication Date: 1996 -
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Rang & dale's pharmacology review by
Call Number: 615.1 DALISBN: 9788131226124Publication Date: 2013 -
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Essentials of Medical Pharmacology by
Call Number: 615.1 TRIISBN: 9789350259375Publication Date: 2013 -
Board review series pharmacology by
Call Number: 615.1076 ROSISBN: 9789351290759Publication Date: 2015
E-Books
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Author: Tofield, Christopher Milson, Alexander Chatu, Sukhdev
Publisher: Wiley-Blackwell
Date Published: 2008 -
Author: Batchelder, Andrew Rodrigues, Charlene Alrifai, Ziad
Publisher: Wiley-Blackwell
Date Published: 2011 -
Author: Scholefield, Donna Sebti
Publisher: M&K Publishing
Date Published: 2015 -
Author: Morgan, Rae Johnson, Margaret Rae, Morgan
Publisher: Wiley-Blackwell
Date Published: 2008 -
Author: McCarthy, Michelle Kockler, Denise R. Wiffen, Phil
Publisher: Oxford University Press
Date Published: 2009
Text Books
E-Books
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Author: Palmer, Michael Chan
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: Perkins, A. C.
Publisher: Taylor & Francis
Date Published: 1999 -
Author: Peters, Jens-Uwe
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: McKay, Gerard A. Walters
Publisher: John Wiley & Sons
Date Published: 2013 -
Author: Schweitzer, Stuart O.
Publisher: Oxford University Press
Date Published: 2006 -
Author: Atkinson, Jr., Arthur J. Abernethy, Darrell R. Daniels
Publisher: Academic Press
Date Published: 2011 -
Author: Springhouse
Publisher: Wolters Kluwer Health
Date Published: 2015 -
Author: Kenakin, Terry
Publisher: Academic Press
Date Published: 2010 -
Author: Griffin, John P. Posner
Publisher: BMJ Books
Date Published: 2013 -
Author: Salmon, D. Michael Salmon, D Michael
Publisher: Wiley
Date Published: 2013 -
Author: Vidya Sagar, G.
Publisher: New Age International
Date Published: 2008 -
Author: Dixit, R.K. Nath.
Publisher: New Age International
Date Published: 2012 -
Author: Scholefield, Donna Sebti
Publisher: M&K Publishing
Date Published: 2015 -
Author: McKay , Gerard A. Reid
Publisher: Wiley-Blackwell
Date Published: 2011 -
Author: Sarker, Dipak Kumar
Publisher: Wiley-Blackwell
Date Published: 2013