Medicinal Chemistry: Course Outline IVA-714

Introduction to medicinal chemistry

• Chemical constitution and biological activity
• Receptor
• Theory
• Structure activity relationships SAR
• Drug metabolism
• Modern concept of rational drug design
• Prodrug
• Combinatorial chemistry
• Computer aided drug design CADD and concept of antisense molecules

Drug targets and drug designing

• Introduction and types of drug targets
• Introduction to molecular modeling and computational chemistry
• Structure based designing
• Ligand based designing
• Various techniques in drug synthesis

General properties chemistry biological action structure activity relationship and the therapeutic applications of the following

Hormones

• Steroidal hormones
• Testosterone
• Progesterone
• Estrogen
• Aldosteron and cortisol
• Proteinous hormones
• Insulin
• Glucagon
• Oxytocin
• Vassopressin

Anti-neoplastic agents

• Tamoxifen
• Fluorouracil
• Mercapturine
• Methotrexate
• Vincristine

Sedatives & hypnotics

• Benzodiazepines
• Barbiturates
• Paraldehyde
• Glutethimide
• Chloral hydrate
• Alcohols

Anaesthetics

• Local anaesthetics
• Procaine
• Lignocaine
• Eucaine
• Cocaine
• Benzocaine
• General anaesthetics
• Cyclopropane
• Halothane
• Nitrous oxide
• Chloroform
• Thiopental sodium
• Ketamine
• Methohexital
• Thioamylal
• Sodium fantanyl citrate
• Tribromo ethanol

Analgesics and antipyretics

• Paracetamol
• Salicylic acid analogues
• Quinolines
• Derivatives
• Pyrazolone and pyrazolodiones
• N- arylanthranilic acids
• Aryl and heteroaryl acetic acid derivatives