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Medicinal Chemistry: Course Outline IVA-714

Medicinal chemistry is the chemistry discipline concerned with the design, development and synthesis of pharmaceutical drugs.

Course Outline

Introduction to medicinal chemistry

  • Chemical constitution and biological activity
  • Receptor
  • Theory
  • Structure activity relationships SAR
  • Drug metabolism
  • Modern concept of rational drug design
  • Prodrug
  • Combinatorial chemistry
  • Computer aided drug design CADD and concept of antisense molecules

Drug targets and drug designing

  • Introduction and types of drug targets
  • Introduction to molecular modeling and computational chemistry
  • Structure based designing
  • Ligand based designing
  • Various techniques in drug synthesis

General properties chemistry biological action structure activity relationship and the therapeutic applications of the following

Hormones

  • Steroidal hormones
  • Testosterone
  • Progesterone
  • Estrogen
  • Aldosteron and cortisol
  • Proteinous hormones
  • Insulin
  • Glucagon
  • Oxytocin
  • Vassopressin

Anti-neoplastic agents

  • Tamoxifen
  • Fluorouracil
  • Mercapturine
  • Methotrexate
  • Vincristine

Sedatives & hypnotics

  • Benzodiazepines
  • Barbiturates
  • Paraldehyde
  • Glutethimide
  • Chloral hydrate
  • Alcohols

Anaesthetics

  • Local anaesthetics
  • Procaine
  • Lignocaine
  • Eucaine
  • Cocaine
  • Benzocaine
  • General anaesthetics
  • Cyclopropane
  • Halothane
  • Nitrous oxide
  • Chloroform
  • Thiopental sodium
  • Ketamine
  • Methohexital
  • Thioamylal
  • Sodium fantanyl citrate
  • Tribromo ethanol

Analgesics and antipyretics

  • Paracetamol
  • Salicylic acid analogues
  • Quinolines
  • Derivatives
  • Pyrazolone and pyrazolodiones
  • N- arylanthranilic acids
  • Aryl and heteroaryl acetic acid derivatives 

Text Books

Relevant Books

E-Books

E-Books