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Drug Synthesis: Course Outline (903)

This course emphasizes the application of organic synthesis to the development of pharmaceutical targets at both the medicinal and process chemistry levels.

Course Outline

Retrosynthetic analysis

Disconnections and reliability of reactions


  • Donor and acceptor
  • Functional group interconversions
  • One group carbon-heteroatom and carbon–carbon disconnections
  • Two group carbon-heteroatom and carbon-carbon disconnections
  • Chemo- regio- and stereo-selectivity considerations
  • Natural reactivity and umpolung
  • One group disconnections
  • Two group disconnections
  • Regioselectivity in synthesis
  • Introduction to ring synthesis
  • Four five and six membered rings
  • Photochemistry in synthesis

Chemistry of protecting groups

  • Protection for alcohols
  • Carbonyl groups
  • Carboxylic groups and amino groups

Applications of synthetic strategies in the total synthesis of selected organic molecules

  • Cholesterol
  • Estrone
  • Progesterone
  • Reserpine
  • Penicillin
  • Prostaglandin
  • Longifolene
  • Taxol

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