Pharmacology & Therapeutics-IIB (PHARM 517): Course Outline (Theory & Practical)

Chemotherapy: 

•  Basic principles of chemotherapy
•  Antibacterials
  • Folate antagonists
  • Sulphonamides
  • Cell wall synthesis inhibitors
  • Penicillin
  • Cephalosporins
  • Carbapenam
  • Monobactam
  • Protein synthesis inhibitors
  • Aminoglycosides
  • Tetracyclines
  • Chloramphenicol
  • Macrolides
  • Nucleic acid synthesis inhibitors
  • Quinolones and miscellaneous Antibiotics
  • Antimycobacterial drugs
  • Urinary tract antiseptics
• Anti-fungals:
• Anti-virals
• Anti-protozoals anti-malarias, anti-amebiasis, anthelmintics  Anti- leishmanials
• Anti-neoplastic drugs

Immunopharmacology:

• Pharmacology of immuno-suppressants and stimulants

Toxicology:

• Pollution and its types (water, air, food)
• Poison and principle of treatment of poisoning.
• Poisoning
  • (Sign & symptom and treatment):
  • Ethanol
  • Barbiturates
  • Digitalis
  • Salicylates
  • Strychnine
  • Narcotics
  • Nicotine
  • Paracetamol
  • Benzodiazepines and organophosphorous compounds
• Chelating agents and their role in poisoning: Dimercaprol, Calcium disodium edentate (Calcium EDTA), Pencillamine and Defroxamine.

NOTE:

• Only an introduction will be given of the banned and obsolete drug products
• While dealing with Pharmacology stress should be laid to the group actions of related drugs and only important differences should be discussed of the individual drugs placed in same group
• Newly introduced drugs should be included in the syllabus while drugs with no clinical and therapeutic values ought to be excluded from syllabus at any time
• The prototype drugs in each group from the latest edition of the recommended books. 

Note:  Practical of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. 

• To study the convulsant effects of strychnine and picrotoxin in frogs and to determine the site of action
• To identify the unknown (convulsant) drug and determine its site of action
• To study the effects of Adrenaline on Human Eyes
• To study the effects of Pilocarpine on Human Eyes
• To study the effect of Homatropine on Human Eyes
• To identify and observe the effects of unknown drugs on Human Eyes
• To study the effects of local anaesthetic drugs on human and the nerve plexus of frog
• To identify and differentiate the effects of unknown drug on human and the nerve plexus of frog
• To demonstrate the effects of Acetylcholine on the Rectus abdominus muscle of frog and competitive pharmacological antagonism by Neuromuscular blocking agent e.g. Gallamine
• To identify the unknown drug by performing pharmacological competitive antagonism on Rectus abdominus muscle of Frog
• To study the anti-coagulant effects of Heparin and oral anti-coagulants on Rabbits
• To identify the unknown anticoagulant drug using Rabbits
• To demonstrate the Graded Dose-Response curve of Acetylcholine on Rabbit intestine
• To identify unknown concentration of Acetycholine from Graded Dose-Response curves
• To demonstrate the general anesthetic effect on rabbits
• To demonstrate the effect of sedatives and hypnotics on rabbits
• To demonstrate the anti-nociceptive (analagesic) effect on mice
• To demonstrate antidepressant effect in rats (forced swimming test, tail suspension test, Yohimbin lethality test)