Drug Stability & Drug development: Course Outline (P2, P-III)
pharmaceutical chemistry is the study and development of new drugs. It involves cures and remedies for diseases, analytical techniques, pharmacology, metabolism, quality assurance, and drug chemistry.
Course Outline
Introduction to drug design and discovery
- Terms used
- Brief discussion of research phases of drug discovery
- Rational drug
- Designing including biological phase
- Chemical phase
- Pre-clincial and clinical phases
- Approval phase
Development of new drugs
- Sources of drugs including serendipity
- Natural source
- Soil
- Shemical libraries
- Brief discussion of drug development pathways
Concept of Pro-drug and application in drug designing
- Application in the formulation development for example I/V
- Oral drugs
Drug designing through studies of metabolites of drugs
- Phase I and phase II reactions
- Role of cytochrome P450
- Oxidative
- Reductive and hydrolytic reaction
Receptor theories
- Concept of agonists and antagonists
- Clark’s theories
- Occupational theory
- Macromolecular perturbation theory
- Brief discussion of drug receptor interaction with special reference to with the
- Mechanism of action of the drug molecule
Introduction and objectives of drug stability studies significance of stability
- Stability testing during development stages of pharmaceutical products
- Types of stability testing
- GMP requirements regarding stability
- Compendial requirements FDA
- Guidelines and stability protocols
- Introduction to product stability of different pharmaceutical dosage form
- Tablets
- Capsule
- Suspensions
- Solutions
- Emulsions
- Ointments
Mode of degradation of drugs kinetic principles in drug stability
- Chemical degradation rates
- Pharmaceutical compatibilities
- Physical degradation
- Kinetics of degradation
- The arhenius equation and calculated stability testing
Physical and photo-stability of pharmaceutical substances in solid and liquid
forms
- Physical degradation
- Factors affecting physical stability
- Kinetics of solid-phase transitions
Chemical factors affecting the stability of drugs
- The role of molecular structure
- Temperature pH and pH rate profiles buffer
- General and acid base
- Nucleophilic and electrophilic catalysis dielectric constant
Stereochemistry of drug molecules and pharmacological activity
- Conformational isomers
- Geometrical isomerism
- Optical isomers and analysis of stereochemistry of the drugs in terms of pharmacological activity
Relevant Books
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An introduction to medicinal chemistry by
Call Number: 615.19 PATISBN: 9780198064046Publication Date: 2009 -
The Organic Chemistry of Drug Design and Drug Action by
Call Number: 615.19 SILISBN: 0126437327Publication Date: 2004
E-Books
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Author: Brown, Nathan Mannhold, Raimund Kubinyi, Hugo
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal
Publisher: Bentham Science Publishers
Date Published: 2010 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal
Publisher: Bentham Science Publishers
Date Published: 2010 -
Author: Nogrady, Thomas Weaver.
Publisher: Oxford University Press
Date Published: 2005 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal Publisher: Bentham Science Publishers Date Published: 2010
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Author: Brown, Nathan Mannhold, Raimund Kubinyi, Hugo
Publisher: John Wiley & Sons
Date Published: 2013 -
Author: Modschiedler, Christa Beaubien Bennett, Denise
Publisher: American Library Association
Date Published: 2014 -
Author: Singh, Jagdamba Dubey.
Publisher: Pragati Prakashan
Date Published: 2009 -
Author: Leszczynski, Jerzy
Publisher: World Scientific Publishing Co.
Date Published: 2005 -
Author: Mitchem, Brian H. Sharnham, Charles L.
Publisher: Nova
Date Published: 2009 -
Author: Nadendla, Rama Rao
Publisher: New Age International
Date Published: 2005
E-Books
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Author: Chatwal, G.R.
Publisher: Himalaya Publishing House
Date Published: 2010 -
Author: Kar, Ashutosh
Publisher: New Age International
Date Published: 2007 -
Author: Zavod, Robin Harrold, Marc
Publisher: ASHP
Date Published: 2014 -
Author: Kar, Ashutosh
Publisher: New Age International
Date Published: 2004 -
Author: Colombo, Giulia P. Ricci.
Publisher: Nova
Date Published: 2009 -
Author: Ortega, Marta P. Gil.
Publisher: Nova
Date Published: 2009 -
Author: Zhang, Wei Cue, Berkeley
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: Kappe, C. Oliver Stadler, Alexander Dallinger, Doris
Publisher: Wiley-VCH
Date Published: 2012 -
Author: Lackey, Karen Roth, Bruce Manhold, Raimund
Publisher: John Wiley & Sons, Incorporated
Date Published: 2013 -
Author: Gohlke, Holger Mannhold, Raimund Kubinyi, Hugo
Publisher: Wiley-VCH
Date Published: 2012 -
Author: Liras, Spiros Bell, Andrew S. Mannhold, Raimond
Publisher: John Wiley & Sons
Date Published: 2014 -
Design (3rd Edition)
Author: Smith, Douglas A. Allerton
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: Chatwal, G.R. Arora, M.
Publisher: Himalaya Publishing House
Date Published: 2008 -
Author: Chatwal, G.R. Arora, M.
Publisher: Himalaya Publishing House
Date Published: 2010