Drug Stability & Drug development: Courser Outline (P1, P-III)
pharmaceutical chemistry is the study and development of new drugs. It involves cures and remedies for diseases, analytical techniques, pharmacology, metabolism, quality assurance, and drug chemistry.
Course Outline
Introduction to molecular modeling and drug development
- Terms used
- Brief discussion of in silico drug designing
- Structure based drug designing
- Ligand based drug designing and role of different software in computer aided
- Drug designing
Example of selected drug design
- Discussion and study of drug designing of different drugs including antipsychotic,
- Antidepressants,
- Antiviral and antibacterial drugs
Molecular targets for development of drugs
- Study of molecular targets including DNA
- RNA
- Nucleotides and other enzymes of cell cycle
Introduction to screening methods
- Study and discussion of low through put screening (LTS)
- High through put
- Screening (HTS)
- Virtual screening and other instrumental techniques that are associated with HTS
Analytical methods
- Application of various analytical methods to the assay of antibiotics
- Benzodiazepines
- Phenol thiazines
- Steroids and sulfonamides
Structure properties of macromolecules
- Study and discussion of macromolecules including protein
- Carbohydrate and fat molecule
- Structure and their role in physiological pathways
Concept of bio-selectivity in drug
- Study the selectivity of drug molecule with the target sites
Enzymes
- Study enzymes
- Their function
- Their role and various types of enzymes in the body
Relevant Books
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An introduction to medicinal chemistry by
Call Number: 615.19 PATISBN: 9780198064046Publication Date: 2009 -
The Organic Chemistry of Drug Design and Drug Action by
Call Number: 615.19 SILISBN: 0126437327Publication Date: 2004
E-Books
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Author: Brown, Nathan Mannhold, Raimund Kubinyi, Hugo
Publisher: John Wiley & Sons
Date Published: 2012 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal
Publisher: Bentham Science Publishers
Date Published: 2010 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal
Publisher: Bentham Science Publishers
Date Published: 2010 -
Author: Nogrady, Thomas Weaver.
Publisher: Oxford University Press
Date Published: 2005 -
Author: ur-Rahman, Atta- Reitz, Allen B. Choudhary, M. Iqbal Publisher: Bentham Science Publishers Date Published: 2010
E-Books
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Author: Brown, Nathan Mannhold, Raimund Kubinyi, Hugo
Publisher: John Wiley & Sons
Date Published: 2013 -
Author: Singh, Jagdamba Dubey.
Publisher: Pragati Prakashan
Date Published: 2009 -
Author: Leszczynski, Jerzy
Publisher: World Scientific Publishing Co.
Date Published: 2005 -
Author: Mitchem, Brian H. Sharnham, Charles L.
Publisher: Nova
Date Published: 2009 -
Author: Chatwal, G.R.
Publisher: Himalaya Publishing House
Date Published: 2010 -
Author: Kar, Ashutosh
Publisher: New Age International
Date Published: 2007 -
Author: Zavod, Robin Harrold, Marc
Publisher: ASHP
Date Published: 2014 -
Author: Kar, Ashutosh
Publisher: New Age International
Date Published: 2004