Drug Stability & Drug development: Courser Outline (P1, P-III)

Introduction to molecular modeling and drug development

• Terms used
• Brief discussion of in silico drug designing
• Structure based drug designing
• Ligand based drug designing and role of different software in computer aided
• Drug designing

Example of selected drug design

• Discussion and study of drug designing of different drugs including antipsychotic,
• Antidepressants,  
• Antiviral and antibacterial drugs

Molecular targets for development of drugs

• Study of molecular targets including DNA
• RNA
• Nucleotides and other enzymes of cell cycle

Introduction to screening methods

• Study and discussion of low through put screening (LTS)
• High through put
• Screening (HTS) 
• Virtual screening and other instrumental techniques that are associated with HTS

Analytical methods

• Application of various analytical methods to the assay of antibiotics
• Benzodiazepines
• Phenol thiazines
• Steroids and sulfonamides

Structure properties of macromolecules

• Study and discussion of macromolecules including protein 
• Carbohydrate and fat molecule
• Structure and their role in physiological pathways

Concept of bio-selectivity in drug

• Study the selectivity of drug molecule with the target sites

Enzymes

• Study enzymes
• Their function
• Their role and various types of enzymes in the body